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Graphical contents list • MISCELLANEOUS PDF (592 K) | |||
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3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers • SHORT COMMUNICATION Yong Sup Lee, Bum Hoon Lee, Seong Jun Park, Soon Bang Kang, Hyewhon Rhim, Jin-Yong Park, Jung-Ha Lee, Seong-Woo Jeong and Jae Yeol Lee SummaryPlus | Full Text + Links | PDF (290 K) | |||
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6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents • SHORT COMMUNICATION Hyen Joo Park, Young-Shin Kim, Jin Sung Kim, Eun-Jin Lee, You-Jin Yi, Hye Jin Hwang, Myung-Eun Suh, Chung-Kyu Ryu and Sang Kook Lee SummaryPlus | Full Text + Links | PDF (288 K) | |||
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Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1 • SHORT COMMUNICATION Lawrence A. Reiter, Ralph P. Robinson, Kim F. McClure, Christopher S. Jones, Matthew R. Reese, Peter G. Mitchell, Ivan G. Otterness, Marcia L. Bliven, Jennifer Liras, Santo R. Cortina et al. SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Binding modes of 6,7 di-substituted 4-anilinoquinoline-3-carbonitriles to EGFR • SHORT COMMUNICATION Nagaraju Akula, Jag Bhalla, Jayalakshmi Sridhar and Nagarajan Pattabiraman SummaryPlus | Full Text + Links | PDF (367 K) | |||
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Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N′-arylthiourea inhibitors of CMV • SHORT COMMUNICATION Jonathan D. Bloom, Russell G. Dushin, Kevin J. Curran, Fran Donahue, Emily B. Norton, Eugene Terefenko, Thomas R. Jones, Adma A. Ross, Boris Feld, Stanley A. Lang and Martin J. DiGrandi SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Lead identification of a potent benzopyranone selective estrogen receptor modulator • SHORT COMMUNICATION Jeffrey A. McKie, Shripad S. Bhagwat, Helen Brady, Mary Doubleday, Leah Gayo, Mathew Hickman, Ravi K. Jalluri, Sak Khammungkhune, Adam Kois, Deborah Mortensen et al. SummaryPlus | Full Text + Links | PDF (281 K) | |||
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Thienopyridine and benzofuran derivatives as potent anti-tumor agents possessing different structure–activity relationships • SHORT COMMUNICATION Ichiro Hayakawa, Rieko Shioya, Toshinori Agatsuma, Hidehiko Furukawa and Yuichi Sugano SummaryPlus | Full Text + Links | PDF (269 K) | |||
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Nitroxide-labeled guanine as an ESR spin probe for structural study of DNA • SHORT COMMUNICATION Akimitsu Okamoto, Takeshi Inasaki and Isao Saito SummaryPlus | Full Text + Links | PDF (375 K) | |||
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Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor • SHORT COMMUNICATION K. Shankaran, Karla L. Donnelly, Shrenik K. Shah, Ravindra N. Guthikonda, Malcolm MacCoss, Sander G. Mills, Sandra L. Gould, Lorraine Malkowitz, Salvatore J. Siciliano, Martin S. Springer et al. SummaryPlus | Full Text + Links | PDF (283 K) | |||
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Exploration of the P2–P3 SAR of aldehyde cathepsin K inhibitors • SHORT COMMUNICATION Eric E. Boros, David N. Deaton, Anne M. Hassell, Robert B. McFadyen, Aaron B. Miller, Larry R. Miller, Margot G. Paulick, Lisa M. Shewchuk, James B. Thompson, Derril H. Willard et al. SummaryPlus | Full Text + Links | PDF (306 K) | |||
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2-Ureidoquinoline: a useful molecular element for stabilizing single cytosine and thymine bulges • SHORT COMMUNICATION Akio Kobori, Takashi Murase, Hitoshi Suda, Isao Saito and Kazuhiko Nakatani SummaryPlus | Full Text + Links | PDF (253 K) | |||
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Exploring QSAR of melatonin receptor ligand benzofuran derivatives using E-state index • SHORT COMMUNICATION Chandana Sengupta, J. Thomas Leonard and Kunal Roy SummaryPlus | Full Text + Links | PDF (264 K) | |||
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2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor • SHORT COMMUNICATION Andrew Mitchinson, John R. Atack, Peter Blurton, Robert W. Carling, José L. Castro, Karen S. Curley, Michael G. N. Russell, George Marshall, Ruth M. McKernan, Kevin W. Moore et al. SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Synthesis and anticancer activity of side chain analogs of the crambescidin alkaloids • SHORT COMMUNICATION Zachary D. Aron, Halina Pietraszkiewicz, Larry E. Overman, Fredrick Valeriote and Carman Cuevas SummaryPlus | Full Text + Links | PDF (278 K) | |||
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Synthesis of S-alkyl  -glutamyl transpeptidase • SHORT COMMUNICATIONChristian Lherbet, Christian Gravel and Jeffrey W. Keillor SummaryPlus | Full Text + Links | PDF (293 K) | |||
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Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors • SHORT COMMUNICATION Baihua Hu, Kristi Yi Fan, Kristie Bridges, Rajiv Chopra, Frank Lovering, Derek Cole, Ping Zhou, John Ellingboe, Guixiang Jin, Rebecca Cowling and Jonathan Bard SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Quantitative structure–polarization relationships (QSPR) study of BTEX tracers for the formation of antibody–BTEX–EDF complex • SHORT COMMUNICATION Taesung Moon, Myung Whan Chi, Myung Ja Choi and Chang No Yoon SummaryPlus | Full Text + Links | PDF (261 K) | |||
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Nucleic acid-binding ligands identify new mechanisms to inhibit telomerase • SHORT COMMUNICATION Pamela K. Dominick, Brian R. Keppler, Jason D. Legassie, Ian K. Moon and Michael B. Jarstfer SummaryPlus | Full Text + Links | PDF (316 K) | |||
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Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid • SHORT COMMUNICATION Webster L. Santos, Brian H. Heasley, Renata Jarosz, Karen M. Carter, Kevin R. Lynch and Timothy L. Macdonald SummaryPlus | Full Text + Links | PDF (276 K) | |||
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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1 • SHORT COMMUNICATION Ariamala Gopalsamy, Scott L. Kincaid, John W. Ellingboe, Thomas M. Groeling, Thomas M. Antrilli, Girija Krishnamurthy, Ann Aulabaugh, Gregory S. Friedrichs and David L. Crandall SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Synthesis and biological activity of some known and putative duloxetine metabolites • SHORT COMMUNICATION F. Kuo, T. A. Gillespie, P. Kulanthaivel, R. J. Lantz, T. W. Ma, D. L. Nelson, P. G. Threlkeld, W. J. Wheeler, P. Yi and M. Zmijewski SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs • SHORT COMMUNICATION Young-Ger Suh, Kwang-Ok Lee, Sung-Hyun Moon, Seung-Yong Seo, Yong-Sil Lee, Seok-Ho Kim, Seung-Mann Paek, Young-Ho Kim, Yun-Sang Lee, Jae Min Jeong et al. SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton • SHORT COMMUNICATION Xudong Geng, Raphaël Geney, Paula Pera, Ralph J. Bernacki and Iwao Ojima SummaryPlus | Full Text + Links | PDF (307 K) | |||
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists • SHORT COMMUNICATION Jeffrey J. Hale, George Doherty, Leslie Toth, Zhen Li, Sander G. Mills, Richard Hajdu, Carol Ann Keohane, Mark Rosenbach, James Milligan, Gan-Ju Shei et al. SummaryPlus | Full Text + Links | PDF (261 K) | |||
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Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists • SHORT COMMUNICATION Jeffrey J. Hale, George Doherty, Leslie Toth, Sander G. Mills, Richard Hajdu, Carol Ann Keohane, Mark Rosenbach, James Milligan, Gan-Ju Shei, Gary Chrebet et al. SummaryPlus | Full Text + Links | PDF (268 K) | |||
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Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPAR selective activators • SHORT COMMUNICATIONZhibin Li, Chenzhong Liao, Ben C. B. Ko, Song Shan, Edith H. Y. Tong, Zihui Yin, Desi Pan, Vincent K. W. Wong, Leming Shi, Zhi-Qiang Ning et al. SummaryPlus | Full Text + Links | PDF (294 K) | |||
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Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides • SHORT COMMUNICATION Nobutoshi Murakami, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii and Motomasa Kobayashi SummaryPlus | Full Text + Links | PDF (268 K) | |||
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Synthesis of new 2′- -C-methyl related triciribine analogues as anti-HCV agents • SHORT COMMUNICATIONKenneth L. Smith, Vicky C. H. Lai, Brett J. Prigaro, Yili Ding, Esmir Gunic, Jean-Luc Girardet, Weidong Zhong, Zhi Hong, Stanley Lang and Haoyun An SummaryPlus | Full Text + Links | PDF (266 K) | |||
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2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators • SHORT COMMUNICATION Anne-Marie Liberatore, Jocelyne Schulz, Jacques Pommier, Marie-Anne Barthelemy, Marion Huchet, Pierre-Etienne Chabrier and Dennis Bigg SummaryPlus | Full Text + Links | PDF (244 K) | |||
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BMS-201620: a selective beta 3 agonist • SHORT COMMUNICATION W. N. Washburn, C. -Q. Sun, G. Bisacchi, G. Wu, P. T. Cheng, P. M. Sher, D. Ryono, A. V. Gavai, K. Poss, R. N. Girotra et al. SummaryPlus | Full Text + Links | PDF (270 K) | |||
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Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase • SHORT COMMUNICATION Hallur Gurulingappa, Phillip Buckhalts, Kenneth W. Kinzler, Bert Vogelstein and Saeed R. Khan SummaryPlus | Full Text + Links | PDF (247 K) | |||
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2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of -secretase • SHORT COMMUNICATION C. V. C. Prasad, Shikha Vig, David W. Smith, Qi Gao, Craig T. Polson, Jason A. Corsa, Valerie L. Guss, Alice Loo, Donna M. Barten, Ming Zheng et al. SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin • SHORT COMMUNICATION Akitsu Ogawa, Chikako Murakami, Shinji Kamisuki, Isoko Kuriyama, Hiromi Yoshida, Fumio Sugawara and Yoshiyuki Mizushina SummaryPlus | Full Text + Links | PDF (337 K) | |||
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(4-Carboxamido)phenylalanine is a surrogate for tyrosine in opioid receptor peptide ligands • SHORT COMMUNICATION Roland E. Dolle, Mathieu Machaut, Blanca Martinez-Teipel, Serge Belanger, Joel A. Cassel, Gabriel J. Stabley, Thomas M. Graczyk and Robert N. DeHaven SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Thyroid receptor ligands. Part 2: Thyromimetics with improved selectivity for the thyroid hormone receptor beta • SHORT COMMUNICATION Jon J. Hangeland, Arthur M. Doweyko, Tamara Dejneka, Todd J. Friends, Pratik Devasthale, Karin Mellström, Johnny Sandberg, Marlena Grynfarb, John S. Sack, Howard Einspahr et al. SummaryPlus | Full Text + Links | PDF (580 K) | |||
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Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi • SHORT COMMUNICATION Tatiana Santana Ribeiro, Leonardo Freire-de-Lima, José Osvaldo Previato, Lucia Mendonça-Previato, Norton Heise and Marco Edilson Freire de Lima SummaryPlus | Full Text + Links | PDF (268 K) | |||
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Phosphonate inhibitors of antigen 85C, a crucial enzyme involved in the biosynthesis of the Mycobacterium tuberculosis cell wall • SHORT COMMUNICATION Stanislav Gobec, Ivan Plantan, Janez Mravljak, Rosalind A. Wilson, Gurdyal S. Besra and Danijel Kikelj SummaryPlus | Full Text + Links | PDF (278 K) | |||
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Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation • SHORT COMMUNICATION Sung-Yu Hong, Kwang-Hoe Chung, Hea-Jung You, Ik Hwa Choi, Mi Jin Chae, Ja-Young Han, Ok-Jai Jung, Soo-Jung Kang and Chung-Kyu Ryu SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen • SHORT COMMUNICATION Sophie Vichier-Guerre, Richard Lo-Man, Valérie Huteau, Edith Dériaud, Claude Leclerc and Sylvie Bay SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Synthesis, absolute stereochemistry and molecular design of the new antifungal and antibacterial antibiotic produced by Streptomyces sp.201 • SHORT COMMUNICATION J. Boruwa, B. Kalita, N. C. Barua, J. C. Borah, S. Mazumder, D. Thakur, D. K. Gogoi and T. C. Bora SummaryPlus | Full Text + Links | PDF (258 K) | |||
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An aminomethylpyrimidine DPP-IV inhibitor with improved properties • SHORT COMMUNICATION Jens-Uwe Peters, Daniel Hunziker, Holger Fischer, Manfred Kansy, Silja Weber, Stéphane Kritter, Aranka Müller, Angelina Wallier, Fabienne Ricklin, Markus Boehringer et al. SummaryPlus | Full Text + Links | PDF (262 K) | |||
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Aminomethylpyridines as DPP-IV inhibitors • SHORT COMMUNICATION Jens-Uwe Peters, Silja Weber, Stéphane Kritter, Peter Weiss, Angelina Wallier, Daniel Zimmerli, Markus Boehringer, Matthias Steger and Bernd-Michael Loeffler SummaryPlus | Full Text + Links | PDF (240 K) | |||
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Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor- type I receptor kinase domain • SHORT COMMUNICATION J. Scott Sawyer, Douglas W. Beight, Karen S. Britt, Bryan D. Anderson, Robert M. Campbell, Theodore Goodson, Jr. , David K. Herron, Hong-Yu Li, William T. McMillen et al. SummaryPlus | Full Text + Links | PDF (289 K) | |||
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Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines • SHORT COMMUNICATION Hong-yu Li, Yan Wang, Lei Yan, Robert M. Campbell, Bryan D. Anderson, Jill R. Wagner and Jonathan M. Yingling SummaryPlus | Full Text + Links | PDF (246 K) | |||
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Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists • SHORT COMMUNICATION K. Shankaran, Karla L. Donnelly, Shrenik K. Shah, Charles G. Caldwell, Ping Chen, Paul E. Finke, Bryan Oates, Malcolm MacCoss, Sander G. Mills, Julie A. DeMartino et al. SummaryPlus | Full Text + Links | PDF (280 K) | |||
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Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis • SHORT COMMUNICATION Laszlo Revesz, Ernst Blum, Franco E. Di Padova, Thomas Buhl, Roland Feifel, Hermann Gram, Peter Hiestand, Ute Manning and Gerard Rucklin SummaryPlus | Full Text + Links | PDF (265 K) | |||
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SAR of benzoylpyridines and benzophenones as p38 MAP kinase inhibitors with oral activity • SHORT COMMUNICATION Laszlo Revesz, Ernst Blum, Franco E. Di Padova, Thomas Buhl, Roland Feifel, Hermann Gram, Peter Hiestand, Ute Manning and Gerard Rucklin SummaryPlus | Full Text + Links | PDF (271 K) | |||
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[3H]-MRE 2029-F20, a selective antagonist radioligand for the human A2B adenosine receptors • SHORT COMMUNICATION Pier Giovanni Baraldi, Mojgan Aghazadeh Tabrizi, Delia Preti, Andrea Bovero, Francesca Fruttarolo, Romeo Romagnoli, Allan R. Moorman, Stefania Gessi, Stefania Merighi, Katia Varani and Pier Andrea Borea SummaryPlus | Full Text + Links | PDF (264 K) | |||
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A mild, efficient and -selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst • SHORT COMMUNICATION Ezzat Rafiee, Shahram Tangestaninejad, Mohammad H. Habibi and Valiollah Mirkhani SummaryPlus | Full Text + Links | PDF (259 K) | |||
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Editorial board • MISCELLANEOUS PDF (276 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (194 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
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